I like MatPat and have watched his vids before but when you're trying to explain how 2 girls (who look the same age btw) are mother and daughter by using alleles and handedness as evidence you're really grasping at straws. Although he almost was on to something. Rosalina was originally going to be Peach's sister. I don't know at what point in development Nintendo ditched that idea but that could explain some of the things he's trying to get at.
Who is Rosalina? Since being introduced in Super Mario Galaxy and Super Mario Galaxy 2, she's started to show up in everything. But what do we REALLY know about this intergalactic gal? Using the clues from the game...a lot more than you might expect. And what her identity reveals brings up A WHOLE LOTTA questions about the Mario franchise...
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