Sure thing.
Let's say you're fighting a lightweight (Kasumi, Pai, anyone). And you just got off your critical burst. Use her 1P, then, in the fastest time possible with no delays, use P , P , 26F+K. Try this out in training. If you did it right, the 26F+K should read as +46 frames when compared to the normal +44. This means that you did it successfully and that your 66F+K would have connected.
Keep working on those combos and reading your frame advantage. The more often it hits +46, the more consistent you're becoming with the combo.
You CAN do it without those combos, but as those are the ones that are guaranteed so long as you have done the inputs at the fastest possible times, I only reccomend them. For mid-weights, I try not to use the combo too much xD only seldomly. Never on heavy weights anymore. But for mid weights, it's the same thing. After the CB, use 33P+K. Then, with the fastest timing possible, P, P, 26F+K