Therefore, Lisa is one of Fame's former mistresses. Not sure if it works in terms of timeline, but maybe Fame financed Isabella/Lisa's sciences studies when they were in love. She used that anagram name after hearing that some of his mistresses were assassinated all around the world.
(meaning btw Maria and Isabella there is a big time gap of course).
I believe Fame was in love with Maria, and raised Helena until her 18th birthday. Then Miyako happened. Then, many years after, right before his death, Fame took Isabella as a mistress when she was 18 herself and looking for a carreer.
Therefore, Lisa is one of Fame's former mistresses. Not sure if it works in terms of timeline, but maybe Fame financed Isabella/Lisa's sciences studies when they were in love. She used that anagram name after hearing that some of his mistresses were assassinated all around the world.
(meaning btw Maria and Isabella there is a big time gap of course).