A 66T OH is the safest option. An i12 throw will generally yield the most damage against a guarding opponent. Repeated 2P's that are +0 or +1 will pressure them to take action to escape the frametrap. If you don't know how to proceed, 5P, 6P, or 6K are decent pokes with follow-ups for most characters.
It all depends on how your opponent reacts.