Kinda you cant get anything big but it can lead into sonething big. Like in VF5: FS Pai is the only character I know of that has a combo off a low. CH 66P+K - 6KP7K - dash - 9KK. All the moves I listed are the same input as in this game just different properties. What I mean by can lead to something big. Is if your opponents back is to a wall. Then some lows will wall stagger if you land them.