On a physical note, I would say Honoka and Ayane with what they went through, with Raidou suffering the most. Mentally on a darker note, I think Helena suffered the most with what Nico revealed to her. I think Marie Rose was traumatized about the whole ordeal and I think Kasumi probably did suffer a relapse of bad memories at the very end. But I think Honoka and Ayane and Raidou suffered the most