I wish I could make a flow chart for this
When someone breaks your takedown you have 3 attack options: p, 2p, and k. K is a mid kick that's unsafe and only launches if they attack (don't recommend using it), p gives you a stun, and 2p gives you a short stun. If you don't do one of these attacks you're at disadvantage.
If you start doing the mid and the low then trying to throw you're setting yourself up for more guessing because they could hold low or mid; if you stick to one attack and start throwing you're risking getting high counter blown.
The best mix up I've come up with is just switching between the low and the mid punch. When they start holding you can switch up to P+K, it will hit any hold on it's recovery so it doesn't matter if they try to hold. If it hits it gives you a sit-down that guarantees 3p. It's also safer than throwing.