I'm leaning a bit towards DOA6, because I see a lot of potential from what was laid out from DOA5/U/LR and the series has attracted a fair bit of fans thanks to DOA5U's & LR's Core Fighters freemium version. Although the DOA stigma may hang over in some capacity, this won't be like the jump from DOA4 to DOA5, where DOA4 turned off a lot of people from the game competitively.
Free Step Dodge
Force_of_Nature
Force_of_Nature
However, a new IP successor could potentially allow the franchise to start anew without the stigma (or majority of the stigma) eclipsing the franchise. Especially if it could be a badass fighting game akin to Yakuza's themes. Would also love to see Team Ninja & SEGA AM2 team up for a collaboration of some sort.