Ye, the 11f 6p is perhaps the biggest deal as that effectively makes it the best mid in the game, which is unbeatable by any other mid as he either beat them in frames or in damage. So Jann got a huge buff with that boost.
On a different field I feel Hitomi got nerfed hard, 236k was/is a big part of my game strategy for the way I was using her. Needless to say at -5 people can now just counter 236k with anything rather than having to think fast, which on its own makes people think even faster increasing the effect of the nerf. I don't know if this is a huge impact on Hitomi players as a whole, as for my personal preference for play. My Hitomi is usually strong when I play with people when they are tired and stuff, as she is extremely effective when people's reaction time goes down, so I don't know if others would feel that as such a huge nerf as I do.
Also you have just pure boosts like Ein's increase to throw and hold, which may not help game mechanics but surely don't hurt their chances of winning.
The clue I would say is that this game is so balanced that even the smaller things helps a lot. This game could easily have just 1 or 2 tiers if you'd where to compare it against say KF or most 2D fighters. By expanding it over 6 tiers for conversation the margins are really small.