In another interview they've mentioned that too. They don't seem to be finished with Uncharted in general (it is their biggest franchise after all) they are just finished with Nate's story. UC4 wrapped his story very well up.
Since UC4 was my first and so far only UC I don't have an as deep connection to Nate anyway. I'm completely fine with some of the other characters taking the lead role.
I'm actually really excited for the Chloe/Nadine pairing this time.
It's bound to be interesting, because they are like polar opposites.
Nadine is the muscle, she's disciplined, goes by the book and as long as you stay true to your part of the deal, she'll be loyal. If you cross her, she'll be a ruthless killer.
Chloe is the brain, she's easy going and doesn't care for any rules. While she's not a bad person, she does look out for herself first and she will easily leave you behind. She does seem to care for friends/family though...
Yeah, this is going to be good.